Cannabigerol (CBG) is one of more than 120 identified cannabinoid compounds found in the plant genus Cannabis. Cannabigerol is the decarboxylated form of Cannabigerolic Acid (CBGa), the parent molecule from which other cannabinoids are synthesized. Cannabigerol is a rare cannabinoid that is a minor constituent of cannabis. During plant growth, most of the cannabigerol is converted into other cannabinoids, primarily tetrahydrocannabinol (THC) or cannabidiol (CBD), leaving about 1% cannabigerol in the plant.
Like THC, CBG reacts with the cannabinoid receptors in the brain. CBG, however, acts as a buffer to the psychoactivity of THC by working to alleviate the paranoia sometimes caused by higher levels of THC. Clinical research reveals that CBG works to fight inflammation, pain, nausea and works to slow the proliferation of cancer cells. Research has also shown it to significantly reduce intraocular eye pressure caused by glaucoma. Strains high in CBG may be beneficial treating conditions such as inflammatory bowel disease, Crohn’s disease, and cancer.
CBG acts as a low-affinity antagonist at the CB1 receptor. CBG pharmacological activity at the CB2 receptor is currently unknown. CBG’s antibacterial effects can alter the overall effects of cannabis. CBG is known to kill or slow bacterial growth, reduce inflammation, (particularly in its acidic CBGA form,) inhibit cell growth in tumor/cancer cells, and promote bone growth.
Another effect CBG has on the brain is that it inhibits the uptake of GABA, a brain chemical that determines how much stimulation a neuron needs to cause a reaction. When GABA is inhibited it can decrease anxiety and muscle tension similar to the effects of cannabidiol (CBD).
When ingested orally, CBG can produce an energetic feeling (referred to by some as a "body high"). Common delivery systems for CBG-rich products are primarily tinctures and gummies.
- Cannabinoids 101
- The Endocannabinoid System
- The Entourage Effect
- About Cannabidiol (CBD)
- About Cannabidiolic Acid (CBDa)
- About Cannabigerol (CBG)
- About Cannabigerolic Acid (CBGa)
- About Cannabinol (CBN)
- About Cannabichromene (CBC)
- About Tetrahydrocannabinol (THC)
- About Tetrahydrocannabivarin (THCV)
- About Terpenes & Terpenoids