Amanita Muscaria Mushrooms
The Legal Magic Mushroom is here.
Amanita Muscaria, commonly known as Fly Agaric or Fly Amanita, is a muscimol mushroom. Arguably the most iconic toadstool species, the fly agaric is a large white-gilled, white-spotted, usually red mushroom, and is one of the most recognizable and widely encountered in popular culture, including art, films, cartoons and video games. Amanita Muscaria has a far-reaching, rich history with roots in many cultures, recreations, and entheogenically in ceremonial settings — and it's still utilized today in many corners of the world. Today's researchers and users have rediscovered what these ancient tribes and indigenous people already knew — this mushroom is more than just a fairytale emblem; it has deep medicinal benefits.
Amanita Muscaria is considered an entheogen. By virtue of its psychoactive effects, Amanita Muscaria is often referred to as a “magic mushroom”, but compared to psilocybin-containing mushrooms, the effects are very different. A. muscaria does not contain psilocybin or psilocin. The active compounds in this mushroom are muscimol and ibotenic acid, with muscimol (a selective agonist for the GABAA receptor) having a sedative, depressant, and deliriant effect.
Although poisonous in it's raw natural form, death due to poisoning from Amanita Muscaria ingestion is extremely rare. Parboiling twice with water draining weakens its toxicity and breaks down the mushroom's psychoactive substances. Care should be taken to prepare the mushrooms properly by thoroughly drying them either in a food dehydrator or oven at a low temperature. The mushrooms should never be eaten raw as this may result in gastrointestinal effects, adverse effects from the ibotenic acid, or allergies to uncooked mushroom proteins. Proper handling and preparation of Amanita Muscaria ingredient ensures safe and effective finished products.
Amanita Muscaria are noted for their hallucinogenic properties, with the main psychoactive constituents being the tryptamines Muscimol and its neurotoxic precursor Ibotenic Acid. Amanita Muscaria also contains small amounts of muscarine, which was originally thought to be the psychoactive compound because it binds with muscarinic acetylcholine receptors. It is present in such small amounts that it is generally treated as insignificant.
Muscimol is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom. Muscimol is a potent and selective orthosteric agonist for the GABAA receptors and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity. Although it does have psychoactive properties, the effect is very different from psilocybin or psilocin. It reacts with the GABAA receptor and when ingested, it can provide feelings of euphoria and tranquility, an altered sense of hearing and taste, changes to sensory perception and vivid dreams.
Ibotenic acid, a neurotoxic secondary metabolite of Amanita muscaria, is the prodrug for muscimol—during the drying of the mushroom, ibotenic acid is decarboxylated into muscimol. Muscimol is five to six times more potent than ibotenic acid, with fewer harmful side effects.
Despite Amanita Muscaria having very strong psychedelic associations in popular culture, it would not be considered psychedelic based on the formal definition. Most compounds considered psychedelic are structurally related to the neurotransmitters serotonin or dopamine (which are 5-HT2A agonists)—for example, the “classic” psychedelics, LSD, psilocybin/psilocin, and mescaline.
Amplified Amanita Muscaria Mushroom Extracts
If the presence of Ibotenic Acid is a concern for you, we recommend formulating with our exclusive Amplified Amanita Mushroom Extracts. These materials have remediated ibotenic acid and contain much higher concentrations of Muscimol than any other concentrates available in the marketplace. Available as 200%, 300%, 400% and 500% muscimol tryptamine concentrations.
Easily customized for CBD product applications.
Our Amanita Muscaria extract products do not contain CBD or other hemp-derived cannabinoids, but can be blended with 20% concentration CBD water soluble powder or 10% concentration Full Spectrum water soluble powder as a custom order. Contact your Account Manager for a custom order quote.
Amanita Mushroom Nano Extract
This premium water-soluble and fully decarboxylated Amanita Muscaria mushroom extract is nanotized through our solventless extraction process. We utilize exclusive ultrasonic technology to break down the chitin walls of the material, making it more bioavailable, potent and infusion ready. Amanita Muscaria mushroom extract powder contains a potent amount of the trytamine active ingredient Muscimol and is derived from 100% fruiting bodies only that have been carefully dehydrated and detoxified. Ideal for product manufacturers.
Exclusive fractionation technology makes it possible to yield amplified extracts with muscimol tryptamine concentrations of up to 500% potency of our standard nanotized mushroom extract in liquid suspension form.
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. As with all dietary supplements, talk to your doctor before adding to your diet if you are pregnant, nursing or have a medical condition for which you are taking any prescription medications. Amanita Muscaria mushrooms have not been approved for human consumption by the Food and Drug Administration.
Frequently Asked Questions
What are the benefits of Amanita Muscaria?
The Amanita Muscaria mushroom has been used medicinally for hundreds of years among tribal peoples in Siberia, as well as in parts of Scandinavia, Eastern Europe and Russia, where it has been used both topically and internally for its analgesic, anti-inflammatory, anti-anxiety, and stimulant properties. Recent research on the mushroom’s pharmacology supports these traditional uses of this mushroom and has also demonstrated that certain compounds exhibit anti-tumor and memory-protecting activities.*
For centuries Amanita Muscaria has been used as a homeopathic medicine. There are reports of its use to treat a variety of illnesses, including pain, depression, anxiety, insomnia, fatigue, and addiction/withdrawal. Despite the warnings from mycologists and lingering tales from mycophobia, more people are becoming curious about this fungus and exploring its use as an entheogen, as well as to treat depression and physical ailments. There are reports of individuals microdosing Amanita Muscaria to boost their energy and productivity.*
Is Amanita Muscaria legal?
Amanita Muscaria is legal in all states in the USA, except in Louisiana, where growing, selling, or possessing Amanita Muscaria (with many other potentially hallucenogenic plants) is prohibited by the Louisiana State Act 159. The main active compound, muscimol, is not considered a controlled substance by the federal government of the United States. Internationally, Amanita Muscaria is legal in most countries with the exceptions of Australia, Romania, The Netherlands, and Thailand.
While cultivation, possession, and distribution of Amanita Muscaria is unregulated by the United States federal government, it has not been approved for human consumption. According to the Erowid Center’s website, “If sold as a supplement, sales must conform to U.S. supplement laws. If sold for consumption as a food or drug, sales are regulated by the FDA.”
Is Amanita Muscaria toxic?
Muscimol and ibotenic acid are lethal in very high doses. There are no studies to determine the levels of toxicity or long-term effects in humans. In much the same way as alcohol, Amanita Muscaria is technically poisonous it can be safely consumed in controlled doses. Care should be taken to prepare the mushrooms properly by thoroughly drying them either in a food dehydrator or oven at a low temperature. The mushrooms should never be eaten raw as this may result in gastrointestinal effects, adverse effects from the ibotenic acid, or allergies to uncooked mushroom proteins. Only proper handling and preparation of Amanita Muscaria ingredients ensures safe and effective finished products.
How much should I take?
Body composition, metabolism and tolerance levels are key factors. Titration and having a clear objective is key to figuring out the optimal dose for yourself. The most recommended approach is starting with a small amount until you are familiar with the effects, and increase as you feel the need for your personal objective.
What is an entheogen?
Entheogens are psychoactive substances, typically of plant origin, that induce alterations in perception, mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwise in sacred contexts.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Consult your healthcare provider before use if you are pregnant, nursing or have a medical condition for which you are are taking any prescription medications. Amanita Muscaria mushrooms have not been approved for human consumption by the Food and Drug Administration.
Clinical Research References
Amanita Muscaria mushrooms may provide powerful anti-inflammation properties*
- The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors | Can J Physiol Pharmacol 2022 Jul 1;100(7):665-678
- Fucomannogalactan and glucan from mushroom Amanita muscaria: Structure and inflammatory pain inhibition | Carbohydrate Polymers Volume 98, Issue 1, 15 October 2013, Pages 761-769
- Mushrooms: A Potential Natural Source of Anti-Inflammatory Compounds for Medical Applications | Mediators Inflamm. 2014; 2014: 805841
- Fly Agaric: A Compendium of History, Pharmacology, Mythology, & Exploration | chacruna 2022
- Effects of Amanita muscaria extract on different in vitro neurotoxicity models at sub-cellular and cellular levels | Food Chem Toxicol 2019 Oct;132:110687
Muscimol from Amanita Muscaria mushrooms may have anti-cancer properties*
- Gel with silver and ultrasmall iron oxide nanoparticles produced with Amanita muscaria extract: physicochemical characterization, microstructure analysis and anticancer properties | Scientific Reports volume 8, Article number: 13260 (2018)
- Increased GABAergic activity inhibits alpha-fetoprotein mRNA expression and the proliferative activity of the HepG2 human hepatocellular carcinoma cell line | J Hepatol 2000 Jan;32(1):85-91
- Functional GABA(A) receptors on human glioma cells | Eur J Neurosci 1998 Jan;10(1):231-8
Muscimol from Amanita Muscaria mushrooms may help reduce fear, stress and anxiety by stimulating GABAA receptors*
- GABAA receptors: structure, function, pharmacology, and related disorders | Journal of Genetic Engineering and Biotechnology volume 19, Article number: 123 (2021)
- Muscimol as an ionotropic GABA receptor agonist | Neurochem Res 2014 Oct;39(10):1942-7
- Extrasynaptic δ-GABAA receptors are high-affinity muscimol receptors | J Neurochem 2019 Apr;149(1):41-53
- Imaging the spread of reversible brain inactivations using fluorescent muscimol | J Neurosci Methods 2008 Jun 15;171(1):30-8
- Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli | Behav Neurosci 1997 Aug;111(4):683-91
- The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol | Exp Brain Res 2001 Jul;139(1):39-52
- Roles of hippocampal GABA(A) and muscarinic receptors in consolidation of context memory and context-shock association in contextual fear conditioning: a double dissociation study | Neurobiol Learn Mem 2012 Jul;98(1):17-24
- Muscimol induces state-dependent learning in Morris water maze task in rats | Brain Res 1995 May 29;681(1-2):126-30
- Binding of muscimol-conjugated quantum dots to GABAC receptors | J Am Chem Soc 2006 Dec 13;128(49):15701-13
- A Method to Quantify Drosophila Behavioral Activities Induced by GABAA Agonist Muscimol | Bio Protoc 2021 Apr 20;11(8):e3982
Muscimol from Amanita Muscaria mushrooms may provide a new approach to the treatment of epilepsy and seizure disorders*
- Anticonvulsant effects of muscimol | Neurology 1980 Jun;30(6):575-81
- Convection-Enhanced Delivery of Muscimol in Patients with Drug-Resistant Epilepsy | Neurosurgery 2019 Jul 1;85(1):E4-E15
- GABA and epilepsy: their complex relationship and the evolution of our understanding | J Child Neurol 1992 Jan;7(1):77-86
- Periodic transmeningeal muscimol maintains its antiepileptic efficacy over three weeks without inducing tolerance, in rats | Neurosci Lett 2011 Apr 25;494(2):135-8
- GABA and epilepsy: basic concepts from preclinical research | Epilepsia 1992;33 Suppl 5:S3
- Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: therapeutic implications. | Epilepsia 2009 Apr;50(4):678-93
- Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats | Neurosci Lett 2010 Jan 29;469(3):421-4
- Anticonvulsant activity of muscimol and gamma-aminobutyric acid against pyridoxal phosphate-induced epileptic seizures | J Neurochem 1981 Jan;36(1):251-7
- Prevention of kainic acid-induced limbic seizures and Fos expression by the GABA-A receptor agonist muscimol | Eur J Neurosci 1997 Jan;9(1):29-40