February 10, 2025
Heart Health Supplements: Five Formulations with Cannabinoids and Mushrooms for Optimal Wellness
Heart health is a major concern in the U.S., with cardiovascular diseases being the leading cause of death. According to the Centers for Disease Control and Prevention (CDC), nearly 697,000 Americans died from heart disease in 2020, accounting for about 1 in every 4 deaths. Given this alarming statistic, it’s essential to focus on proactive heart health and consider supplements that support cardiovascular function, reduce inflammation, and improve overall wellness. Incorporating functional mushrooms and cannabinoids can be an innovative approach to heart health.
Here are five different supplement formulations designed to support heart health, each using a unique medium like gummies, capsules, tinctures, beverages, and powder blends.

#1. Heart Health Gummies Formulation
Key Ingredients:
- CBD (10mg per gummy): Helps reduce inflammation and oxidative stress, two major contributors to heart disease. CBD can lower blood pressure and improve endothelial function (Source: Journal of Clinical Investigation, 2017).
- Lion’s Mane Mushroom (250mg): Known for its neuroprotective effects, Lion’s Mane supports cognitive function and reduces anxiety, which can help lower stress-related heart risks.
- Turmeric (Curcumin, 200mg): Known for its anti-inflammatory properties, turmeric has been shown to lower cholesterol levels and reduce inflammation in the blood vessels (Source: Journal of Nutritional Biochemistry, 2009).
- Coenzyme Q10 (50mg): Supports mitochondrial function and energy production in heart cells. CoQ10 is essential for maintaining healthy blood pressure and overall heart health (Source: American Journal of Clinical Nutrition, 2005).
- Ginger Extract (100mg): Can reduce inflammation and lower blood pressure. Ginger has been shown to enhance blood circulation and reduce LDL cholesterol (Source: Journal of Hypertension, 2015).
Serving Size: 2 gummies per day.
Market Data:
Gummies have seen exponential growth in the wellness market, with the global gummy supplements market expected to reach $6.43 billion by 2027, growing at a CAGR of 9.4% from 2020 to 2027 (Grand View Research).
#2. Heart Health Capsules Formulation
Key Ingredients:
- CBD (25mg per capsule): Anti-inflammatory and antioxidant properties that help prevent plaque buildup in arteries.
- Reishi Mushroom (200mg): Reduces high blood pressure and improves heart function, making it a great adaptogen for heart health (Source: Phytotherapy Research, 2012).
- Hawthorn Berry Extract (100mg): Traditionally used to treat heart-related ailments, it improves blood flow and strengthens the heart muscle.
- Omega-3 Fatty Acids (1000mg): Omega-3s, especially EPA and DHA, have been shown to reduce the risk of arrhythmias and lower blood pressure (Source: Journal of the American College of Cardiology, 2004).
- Magnesium (200mg): Essential for heart rhythm regulation and supports healthy blood vessels.
Serving Size: 1 capsule per day.
Market Data:
The global market for cardiovascular supplements is projected to reach $1.7 billion by 2025, driven by an aging population and increasing awareness of heart disease prevention.
#3. Heart Health Tincture Formulation
Key Ingredients:
- CBD (20mg per serving): Reduces systemic inflammation and improves vascular health.
- L-Theanine (100mg): Helps to lower stress, improve relaxation, and reduce blood pressure (Source: Journal of Clinical Psychology, 2009).
- Ashwagandha (150mg): This adaptogen helps reduce cortisol levels, which is key in preventing stress-related heart disease (Source: Journal of Clinical Psychopharmacology, 2012).
- Cordyceps Mushroom Extract (150mg): Enhances cardiovascular endurance and oxygen uptake, improving heart function during physical activity (Source: International Journal of Medicinal Mushrooms, 2004).
- Vitamin D3 (1000 IU): Supports calcium regulation and overall heart health. Low vitamin D levels have been linked to cardiovascular diseases (Source: Circulation, 2008).
Serving Size: 1-2 droppers per day.
Market Data:
The global market for tinctures is expanding as more consumers turn to liquid extracts for faster absorption. The growth of liquid herbal supplements is anticipated to reach 7.5% CAGR by 2027.
#4. Heart Health Beverage Formulation
Key Ingredients:
- CBD (25mg per serving): Helps with inflammation, regulates blood pressure, and improves endothelial function.
- Green Tea Extract (300mg, EGCG): Powerful antioxidant properties that help with fat metabolism and reduce LDL cholesterol levels (Source: American Journal of Clinical Nutrition, 2006).
- Turmeric (200mg): Combats inflammation and improves blood vessel health.
- Pomegranate Extract (200mg): Rich in polyphenols, pomegranate has shown promise in lowering blood pressure and improving cholesterol (Source: Journal of Nutritional Biochemistry, 2013).
- Cayenne Pepper (50mg): Known to increase circulation and reduce blood pressure (Source: Journal of Clinical Pharmacology, 2001).
Serving Size: 1 beverage per day.
Market Data:
The global market for functional beverages is expected to grow from $128.2 billion in 2020 to $208.1 billion by 2027, with consumers seeking beverages with health benefits like heart health support.
#5. Heart Health Powder Single Serve Formulation
Key Ingredients:
- CBD (30mg per serving): Reduces systemic inflammation, helps lower high blood pressure, and supports healthy arteries.
- Coenzyme Q10 (200mg): Vital for maintaining cardiovascular health, CoQ10 supports healthy blood vessel function and heart muscle strength (Source: European Heart Journal, 2013).
- Beetroot Extract (500mg): Boosts nitric oxide production, improving blood circulation and lowering blood pressure (Source: Hypertension, 2008).
- Magnesium (400mg): Crucial for heart rhythm regulation and overall cardiovascular health.
- L-Arginine (1000mg): An amino acid that helps improve circulation by increasing nitric oxide levels.
Serving Size: 1 single-serve packet mixed in water, once per day.
Market Data:
The global market for powdered supplements is growing rapidly, particularly in the heart health category, as more people seek to improve cardiovascular health with convenient, on-the-go products.
Why These Formulations Matter
The demand for heart health supplements is growing as cardiovascular diseases continue to be a leading cause of death in the U.S. and worldwide. With the CDC reporting that nearly 697,000 people died from heart disease in 2020, the need for preventive measures has never been higher. By combining cannabinoids with powerful adaptogens and functional ingredients like mushrooms, antioxidants, and vitamins, these formulations offer comprehensive support for cardiovascular health, mental well-being, and overall wellness.
How Covalent Can Help
Covalent can help you develop customized heart health formulations that combine cannabinoids and nutraceuticals in innovative ways. Our cGMP-compliant manufacturing ensures that every product meets the highest standards of safety and efficacy. With our low minimum order quantities (MOQs) and fast turnaround times, we make it easy to bring your heart health products to market quickly.
Ready to create your own heart-healthy supplement?
Contact Covalent today to explore how we can help you design, formulate, and manufacture your next big product. Visit Covalent’s Registration Page or call 702-766-4367 for inquiries.

About Rich Weisner
I specialize in helping businesses create, formulate, and bring innovative products to market. With expertise in the development of custom CBD formulations, nutraceuticals, and functional mushrooms, I work closely with clients to craft high-quality products that meet their unique needs.
My goal is to help businesses scale and succeed by offering personalized support, industry knowledge, and access to cutting-edge manufacturing technology. Let’s connect and explore how we can collaborate to bring your product ideas to life!
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