February 4, 2025
5 Brain Health Supplements Off the Radar That Should Be in Your Gummy Formulation

When it comes to cognitive health, consumers are increasingly seeking innovative, effective supplements to enhance memory, focus, and mental clarity. While many are familiar with the basics like Omega-3s or Ginkgo Biloba, there are several lesser-known brain health supplements that hold significant promise. These ingredients can be particularly effective when combined in a gummy format, as it offers a tasty, convenient, and easy-to-dose delivery method.
Here are five brain health supplements that deserve a place in your next gummy formulation:
#1. Phosphatidylserine (PS)
Serving Size: 100-200 mg per gummy
What It Does: Phosphatidylserine is a phospholipid that plays a crucial role in maintaining the structure of brain cells and supporting communication between them. It’s shown to improve memory, cognitive function, and focus, especially in aging adults. Studies have demonstrated that phosphatidylserine can reduce cognitive decline, enhance attention, and support short-term memory.
Market Insight: According to Grand View Research, the global cognitive supplements market size was valued at $13.1 billion in 2020 and is expected to grow at a CAGR of 6.6% from 2021 to 2028. Phosphatidylserine is well positioned as an effective ingredient within this expanding market.
#2. Bacopa Monnieri
Serving Size: 300-600 mg per gummy
What It Does: Bacopa Monnieri is a traditional herb used for improving memory, reducing anxiety, and enhancing focus. Studies have shown that it can improve cognitive performance and may help reduce symptoms of stress and anxiety. It works by supporting serotonin and dopamine levels in the brain, making it ideal for those looking to boost mental clarity and mood.
Market Insight: Bacopa Monnieri has been gaining traction in the cognitive health space, especially as consumers turn toward adaptogens and natural alternatives to manage stress and support brain health. ResearchAndMarkets forecasts the global adaptogen market will reach $16.6 billion by 2027, with Bacopa being a key contributor to this rise.
#3. N-Acetyl L-Tyrosine (NALT)
Serving Size: 250-500 mg per gummy
What It Does: N-Acetyl L-Tyrosine (NALT) is an amino acid derivative that supports brain function during stressful situations. It helps increase levels of important neurotransmitters like dopamine and norepinephrine. NALT has been shown to improve mental performance and cognitive function, especially under stress. It is ideal for those who experience brain fog or struggle with focus and clarity during mentally taxing activities.
Market Insight: The global market for amino acid-based supplements is projected to grow from $8.9 billion in 2021 to $14.6 billion by 2028, with NALT playing an increasing role as people seek ways to manage stress and improve mental performance. It’s an exciting addition for gummies targeting cognitive health.
#4. Lion’s Mane Mushroom
Serving Size: 500-1000 mg per gummy
What It Does: Lion’s Mane Mushroom is a nootropic known for promoting neurogenesis (the growth of new brain cells). Studies have found that it can improve memory, increase focus, and even help fight cognitive decline. The active compounds in Lion’s Mane, such as hericenones and erinacines, stimulate nerve growth factor (NGF), which is crucial for the maintenance of brain cells.
Market Insight: The global market for functional mushrooms is booming, and Lion’s Mane is at the forefront. The functional mushroom market is expected to reach $34.6 billion by 2027, with Lion’s Mane contributing significantly to that growth due to its brain-boosting properties.
#5. Rhodiola Rosea
Serving Size: 200-400 mg per gummy
What It Does: Rhodiola Rosea is a well-known adaptogen that helps the body adapt to stress and promotes mental clarity and focus. It has also been shown to improve endurance and reduce fatigue. This herb is particularly beneficial for enhancing energy levels, especially during mentally demanding tasks. Rhodiola has been studied for its potential to reduce cortisol levels, improving mood and cognitive performance.
Market Insight: As the demand for adaptogens grows, Rhodiola has seen a significant rise in popularity. The adaptogen market is growing rapidly, with Rhodiola projected to see continued growth due to its cognitive and stress-reducing benefits. The market for adaptogenic supplements is expected to reach $14 billion by 2026, driven by the increased focus on mental health and wellness.
Why Gummies Are the Perfect Medium for These Supplements
Gummies are a great way to deliver these brain-boosting supplements because they are not only convenient but also offer enhanced bioavailability. Unlike pills or capsules, gummies are easy to consume, have great flavor, and allow consumers to enjoy the benefits of each supplement without having to swallow multiple pills. With the market moving towards more natural, bioavailable, and convenient products, gummies provide the perfect platform to deliver potent cognitive supplements.
Clinical Research References
Phosphatidylserine Clinical Research References
Phosphatidylserine Clinical Research References
Phosphatidylserine (PS) is a phospholipid abundant in the brain, integral to neuronal membrane function and signaling. Research has explored its potential benefits for cognitive health, particularly in aging populations. Below is a summary of key clinical studies supporting brain health claims:
Age-Related Cognitive Decline:
- A review of multiple clinical trials indicated that PS supplementation might alleviate age-related declines in memory, learning, concentration, and mood. Notably, 16 double-blind studies demonstrated promising results in these areas. Source: grc.com
Mild Cognitive Impairment:
- A 2020 review of three clinical trials found that PS is likely effective for enhancing cognitive function in older individuals with mild cognitive impairment. The mechanism remains unclear, but the findings suggest potential benefits. Source: en.wikipedia.org
Memory Function in Elderly with Memory Complaints:
- A study involving elderly Japanese subjects with memory complaints reported that soybean-derived PS improved memory functions. Participants who took PS supplements showed significant improvements compared to those who took a placebo. Source: en.wikipedia.org
Cognitive Function in Alzheimer’s Disease:
- Some studies have suggested that PS supplementation may aid in managing symptoms of Alzheimer’s disease. However, more rigorous trials are needed to confirm these findings. Source: alzdiscovery.org
Safety and Tolerability:
- Clinical studies have shown that PS is well-tolerated with no serious adverse events reported in short trials. It may slightly reduce blood pressure, but information on long-term safety is not available. Source: alzdiscovery.org
While these studies suggest potential cognitive benefits of phosphatidylserine supplementation, it’s important to note that results can vary, and more rigorous, large-scale trials are necessary to establish definitive conclusions. As always, consult with a healthcare professional before starting any new supplement regimen.
Bacopa Monnieri Clinical Research References
Bacopa Monnieri Clincial Research References
Bacopa monnieri, commonly known as Brahmi, is an herb traditionally used in Ayurvedic medicine for its potential cognitive-enhancing properties. Several clinical studies have investigated its effects on brain health:
Systematic Review of Cognitive Effects:
- A systematic review analyzed multiple randomized, controlled human clinical trials and found that Bacopa monnieri may improve cognitive performance, particularly in memory and learning. Source: research.monash.edu
Cognitive Enhancement in Healthy Older Adults:
- A randomized, double-blind, placebo-controlled trial involving healthy adults over 55 years old assessed the effects of Bacopa monnieri supplementation combined with cognitive training. The study suggested potential cognitive benefits, though further research is needed to confirm these findings. Source: frontiersin.org
Memory and Cognitive Skills in Adults:
- A recent randomized, double-blind, placebo-controlled study evaluated the impact of Bacopa monnieri extract on memory and cognitive skills in adults. The results indicated improvements in these areas, supporting the herb’s potential cognitive-enhancing effects. Source: gavinpublishers.com
Neuroprotective and Cognitive-Enhancing Effects:
- A systematic review highlighted Bacopa monnieri’s neuroprotective properties, including its ability to repair damaged neurons, restore synaptic function, and improve nerve transmission. The review concluded that Bacopa monnieri could enhance cognitive functions and provide neuroprotection. Source: mdpi.com
While these studies suggest potential cognitive benefits of Bacopa monnieri supplementation, it’s important to note that results can vary, and more rigorous, large-scale trials are necessary to establish definitive conclusions. As always, consult with a healthcare professional before starting any new supplement regimen.
N-Acetyl L-Tyrosine Clinical Research References
N-Acetyl L-Tyrosine Clinical Research References
N-Acetyl L-Tyrosine (NALT) is a modified form of the amino acid L-Tyrosine, known for its role in neurotransmitter synthesis, particularly dopamine, norepinephrine, and epinephrine. These neurotransmitters are crucial for cognitive functions, including memory, attention, and stress response. While direct clinical research on NALT is limited, studies on L-Tyrosine provide insights into its potential brain health benefits:
Cognitive Performance Under Stress:
- A review in the Journal of Psychiatry and Neuroscience examined the effects of tyrosine supplementation on individuals under stress or cognitive demands. The findings suggest that tyrosine may help maintain cognitive function during acute stressors, such as extreme temperatures or sleep deprivation. Source: academic.oup.com
Memory and Cognitive Flexibility:
- Research indicates that tyrosine supplementation can enhance working memory and cognitive flexibility during mentally demanding tasks. In a study, participants who took tyrosine performed better in tasks requiring task-switching and updating working memory compared to those who took a placebo. Source: nypost.com
Wakefulness During Sleep Deprivation:
- Tyrosine has been studied for its potential to counteract cognitive decline due to sleep deprivation. One study found that individuals who consumed tyrosine remained alert for an additional three hours compared to those who did not, suggesting its role in sustaining cognitive performance when sleep-deprived. Source: nypost.com
It’s important to note that while these studies highlight the potential cognitive benefits of tyrosine supplementation, direct clinical research on N-Acetyl L-Tyrosine is limited. As always, consult with a healthcare professional before starting any new supplement regimen.
Lion’s Mane Mushroom Clinical Research References
Lion’s Mane Mushroom Clinical Rsearch References
Lion’s Mane mushroom (Hericium erinaceus) has been traditionally used in East Asian medicine and has recently garnered attention for its potential cognitive benefits. Several clinical studies have explored its effects on brain health:-
Cognitive Function in Mild Cognitive Impairment:
- A double-blind, placebo-controlled trial investigated the effects of Lion’s Mane on individuals with mild cognitive impairment. Participants who consumed Lion’s Mane supplements showed significant improvements in cognitive function compared to the placebo group. The study concluded that Lion’s Mane might be effective in enhancing cognitive function in this population. Source: alzdiscovery.org
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Mood and Cognitive Function in Healthy Adults:
- A randomized, double-blind, placebo-controlled pilot study examined the acute and chronic effects of Lion’s Mane supplementation on mood and cognitive function in healthy young adults. The results indicated that a single dose of Lion’s Mane improved cognitive task performance, and a 28-day supplementation period showed a trend towards reduced subjective stress. These findings suggest potential cognitive and mood benefits of Lion’s Mane in healthy individuals. Source: mdpi.com
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Neurotrophic Properties:
- Research has identified active compounds in Lion’s Mane that promote nerve growth factor (NGF) synthesis, which is essential for the growth and maintenance of neurons. These neurotrophic properties suggest that Lion’s Mane may support neuronal health and cognitive function. Source: restorativemedicine.org
Rhodiola Rosea Clinical Research References
Rhodiola Rasea Clinical Research References
Rhodiola rosea is an adaptogenic herb traditionally used to enhance physical and mental performance. Several clinical studies have investigated its potential benefits for brain health:
Systematic Review of Randomized Clinical Trials:
- A systematic review analyzed randomized clinical trials to assess the effectiveness of Rhodiola rosea. The review concluded that Rhodiola rosea might have beneficial effects on physical and mental performance, though the quality of the studies varied. Source: magistralbr.caldic.com
Systematic Review on Cognitive Functions and Mental Performance:
- A systematic review evaluated the efficacy of Rhodiola rosea in terms of cognitive functions and mental performance, including symptoms of life-stress, fatigue, and burnout. The review found that Rhodiola rosea may alleviate these symptoms, suggesting potential cognitive benefits. Source: mdpi.com
Systematic Review on Physical and Mental Fatigue:
- A systematic review analyzed the effects of Rhodiola rosea on physical and mental fatigue. The review indicated that Rhodiola rosea might reduce fatigue and improve cognitive function, though the quality of the included studies was suboptimal. Source: alzdiscovery.org
While these studies suggest potential cognitive benefits of Rhodiola rosea, it’s important to note that the quality of some studies is variable, and more rigorous, large-scale trials are necessary to establish definitive conclusions. As always, consult with a healthcare professional before starting any new supplement regimen.
How Covalent Can Help
At Covalent, we specialize in formulating and manufacturing high-quality cannabinoid and nutraceutical products, including brain health gummies. Our cGMP-compliant manufacturing ensures that every product is made to the highest standards of safety and quality. With our low MOQs and quick turnaround times, we help businesses create high-impact products that consumers love.
If you’re looking to develop your own brain health gummies or any other nutraceutical product, Covalent is here to help you every step of the way. From formulation to packaging, we provide flexible solutions to bring your product to market quickly and efficiently.
Ready to create your next big product? Contact us today to see how Covalent can help you formulate the best brain-boosting supplements.

About Rich Weisner
I specialize in helping businesses create, formulate, and bring innovative products to market. With expertise in the development of custom CBD formulations, nutraceuticals, and functional mushrooms, I work closely with clients to craft high-quality products that meet their unique needs.
My goal is to help businesses scale and succeed by offering personalized support, industry knowledge, and access to cutting-edge manufacturing technology. Let’s connect and explore how we can collaborate to bring your product ideas to life!
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