January 27, 2025
Top 5 Nutraceutical Ingredients To Keep On Your Radar In 2025
In today’s health-conscious world, consumers are increasingly looking for supplements that provide targeted benefits to support heart health, immune function, joint health, and more. Whether you’re developing a new product or seeking ways to enhance your wellness routine, incorporating key ingredients like Nattokinase, Berberine, Quercetin, Serratiopeptidase, and Taurine into your formulations can make a substantial difference. These powerful nutraceuticals are not only gaining popularity but are backed by clinical studies demonstrating their effectiveness.
Let’s dive into why these five supplements are ones to keep on your radar in 2025, the benefits they offer, and how Covalent can help you bring these powerhouse ingredients to market.
#1. Nattokinase: The Heart Health Hero
Nattokinase, derived from fermented soybeans, is renowned for its potential to support cardiovascular health by promoting healthy blood circulation and reducing blood clot formation. As an enzyme, it helps break down fibrin, a protein involved in clotting, making it a promising ingredient for those looking to manage their heart health naturally.
Clinical Benefits:
A study in the Journal of Nutritional Science and Vitaminology found that nattokinase supplementation led to significant improvements in blood flow and blood pressure regulation.
Market Growth:
The global cardiovascular supplement market is projected to reach $8.8 billion by 2027, with Nattokinase emerging as a key player in the sector.
#2. Berberine: A Natural Powerhouse for Blood Sugar and Metabolism
Berberine is a plant alkaloid traditionally used in Chinese medicine and has recently gained attention for its potential to help manage blood sugar levels, support weight management, and improve insulin sensitivity. Studies have shown that berberine can be just as effective as some pharmaceutical medications in lowering blood sugar.
Clinical Benefits:
Research published in Metabolism journal demonstrated that berberine significantly improved blood sugar control and cholesterol levels, supporting its role in managing type 2 diabetes.
Market Growth:
The global market for blood sugar management supplements is expected to grow by 5.2% annually, with berberine becoming a top choice for consumers seeking natural metabolic support.
#3. Quercetin: The Anti-inflammatory and Antioxidant Champion
Quercetin is a flavonoid found in fruits and vegetables like apples and onions, known for its powerful anti-inflammatory and antioxidant effects. This supplement is often used to support immune function, reduce allergy symptoms, and promote general well-being.
Clinical Benefits:
A study published in Frontiers in Pharmacology highlighted quercetin’s ability to reduce inflammation and improve immune responses, making it a powerful tool for allergy and immune health.
Market Growth:
The global anti-inflammatory supplement market is projected to grow significantly, driven by increasing demand for natural alternatives to traditional medications.
#4. Serratiopeptidase: The Joint and Muscle Recovery Support
Serratiopeptidase, an enzyme derived from the bacteria Serratia E15, has gained traction for its ability to reduce inflammation and support muscle recovery. It is commonly used for joint health, post-surgery healing, and muscle pain relief.
Clinical Benefits:
Studies in the Journal of Clinical and Diagnostic Research have shown that serratiopeptidase helps to alleviate joint pain, improve mobility, and reduce swelling.
Market Growth:
The global joint health supplement market is expected to reach $5.5 billion by 2026, with serratiopeptidase playing an important role in both post-surgical recovery and chronic joint inflammation.
#5. Taurine: The Energy and Heart Health Essential
Taurine is a naturally occurring amino acid that supports muscle function, heart health, and brain function. Known for its role in energy metabolism and hydration, taurine also plays a vital role in reducing oxidative stress and inflammation.
Clinical Benefits:
A study published in the American Journal of Hypertension revealed taurine’s positive effects on blood pressure regulation and heart health. Additionally, taurine supplementation has been linked to improved exercise performance and muscle recovery.
Market Growth:
As consumers continue to focus on muscle health and cardiovascular well-being, taurine is expected to remain a strong contender in the global amino acid supplement market, which is forecasted to grow by 7.3% CAGR over the next few years.
Clinical Research References
Nattokinase Clinical Research References
Nattokinase Clinical Research References
Nattokinase, an enzyme derived from the traditional Japanese fermented soybean food called natto, has been the subject of various clinical studies exploring its potential health benefits, particularly in cardiovascular health. Below is a selection of clinical research references on nattokinase:
Nattokinase and Its Effects on Cardiovascular Health:
This review discusses recent studies highlighting nattokinase’s role as a natural thrombolytic agent, its production methods, and its clinical applications in managing cardiovascular diseases. Read The Article…
Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation:
This review delves into the advancements of nattokinase across various domains, including its emerging roles in Alzheimer’s disease prevention and the treatment of retinal diseases. Read The Article…
Nattokinase Supplementation and Cardiovascular Risk Factors:
A Meta-Analysis of Randomized Controlled Trials: This meta-analysis evaluates the cardiovascular efficacy of nattokinase, analyzing its impact on blood pressure, lipid profiles, and other cardiovascular risk factors. Read The Article…
Nattokinase in Cardiovascular Diseases and Inflammation and Dyslipidemias:
This clinical trial aims to evaluate the effect of nattokinase on inflammation and markers of cardiovascular risk in participants with dyslipidemia. Read The Article…
Nattokinase Atherothrombotic Prevention Study (NAPS):
This randomized, double-blind, placebo-controlled trial investigates whether nattokinase can reduce the progression of subclinical atherosclerosis and cognitive decline by decreasing atherothrombotic risk. Read The Article…
Nattokinase in Hyperlipidemia:
This study examines the long-term effect of nattokinase on blood pressure, lipid profiles, and fibrinolytic factors in dyslipidemic patients. Read The Article…
These studies provide insights into the potential therapeutic applications of nattokinase, particularly concerning cardiovascular health and related conditions.
Berberine Clinical Research References
Berberine Clinical Research References
Berberine, a natural compound found in various plants, has been the subject of numerous clinical studies investigating its potential therapeutic effects. Below is an overview of some key areas of research:
Non-Alcoholic Fatty Liver Disease (NAFLD):
A meta-analysis published in March 2024 evaluated the efficacy and safety of berberine in treating NAFLD. The study concluded that berberine shows promise in improving liver function and metabolic parameters in NAFLD patients. Read The Article…
Metabolic Health and Weight Management:
Berberine has gained attention for its potential role in weight loss and metabolic health. Preliminary studies suggest that berberine may aid in weight reduction and improve metabolic markers. However, comprehensive clinical trials are limited, and more rigorous research is needed to confirm these effects. Read The Article…
Cardiovascular and Liver Diseases:
Research indicates that berberine may have beneficial effects on cardiovascular and liver diseases. Clinical and preclinical studies have explored its potential in reducing insulin resistance and lowering blood lipid levels, suggesting promise for conditions like polycystic ovary syndrome (PCOS). Read The Article…
Cancer Research:
Preliminary studies have investigated berberine’s potential anticancer properties. While initial findings are encouraging, comprehensive clinical trials are necessary to determine its efficacy and safety in cancer treatment. Read The Article…
Pharmacokinetics and Safety:
A clinical trial registered under NCT05463003 focused on the pharmacokinetics of berberine, including its absorption, metabolism, and excretion. The study monitored vital parameters such as blood pressure and heart rate to assess safety profiles. Read The Article…
Digestive Health:
A randomized clinical trial investigated the effects of berberine hydrochloride in patients with diarrhea-predominant irritable bowel syndrome (IBS). The study aimed to assess berberine’s efficacy in alleviating IBS symptoms. Read The Article…
Obesity Parameters:
Research has explored berberine’s impact on obesity-related parameters, suggesting potential benefits in weight management. However, further studies are required to establish definitive conclusions. Read The Article…
While these studies highlight the potential therapeutic applications of berberine, it’s important to note that research is ongoing. Individuals considering berberine supplementation should consult healthcare professionals to ensure safety and appropriateness for their specific health conditions.
Quercetin Clinical Research References
Quercitin Clinical Research References
Quercetin, a naturally occurring flavonoid found in various fruits and vegetables, has been the subject of multiple clinical studies exploring its potential therapeutic benefits. Here are some notable references:
Quercetin in Fanconi Anemia:
A Phase 1 study evaluated the safety, tolerability, and pharmacokinetics of quercetin in patients with Fanconi Anemia. Twelve participants, aged between 3 and 21 years, received oral quercetin twice daily for four months. The study concluded that quercetin was well tolerated at all dose levels. Read The Article…
Quercetin in Chronic Obstructive Pulmonary Disease (COPD):
A randomized clinical trial investigated the safety of quercetin supplementation in individuals with COPD. The study aimed to determine the appropriate dosage required to achieve a fourfold increase in plasma quercetin levels, which had previously been associated with reduced lung inflammation in preclinical models. Read The Article…
Quercetin in Chronic Kidney Disease (CKD):
The Mayo Clinic conducted a study to assess the efficacy of a three-day treatment regimen combining dasatinib and quercetin on cellular senescence and mesenchymal stem cell functionality in patients with CKD. The primary objectives were to evaluate the clearance of senescent cells and improvements in stem cell function. Read The Article…
Quercetin in Alzheimer’s Disease:
A study titled “ALSENLITE: Senolytics for Alzheimer’s Disease” aimed to measure target engagement in cerebrospinal fluid and blood, and to establish the feasibility and safety of a treatment combining dasatinib and quercetin in adults with early-stage symptomatic Alzheimer’s Disease. Read The Article…
Quercetin in Cancer Prevention:
A systematic review evaluated the therapeutic activity of quercetin in women with Polycystic Ovary Syndrome (PCOS). Out of 253 articles considered, eight were eligible, including three clinical trials and five animal studies. The findings suggested that quercetin could reduce luteinizing hormone (LH), testosterone levels, and insulin resistance. Read The Article…
These studies highlight the diverse potential applications of quercetin in clinical settings. However, it’s important to note that while preliminary results are promising, further research is necessary to fully understand the efficacy and safety of quercetin across various health conditions.
Serratiopeptidase Clinical Research References
Serratiopeptidase Clinical Research References
Serratiopeptidase, a proteolytic enzyme derived from the bacterium Serratia marcescens, has been the subject of various clinical studies investigating its therapeutic potential, particularly in reducing inflammation and pain. Below is a selection of notable clinical research references:
Efficacy of Serratiopeptidase after Impacted Third Molar Surgery: A Randomized Controlled Clinical Trial (2021)
Authors: Zaid Tamimi, Rola Al Habashneh, Islam Hamad, Mutasim al-Ghazawi, Ala’ Abu Roqa’a, Hamza Kharashgeh
Journal: BMC Oral Health
Summary: This study assessed the therapeutic effects of serratiopeptidase in patients undergoing surgical removal of impacted mandibular third molars. The randomized clinical trial compared serratiopeptidase and paracetamol against a placebo and paracetamol over five days. Results indicated that serratiopeptidase significantly improved trismus and swelling compared to the control group, though no significant difference in reported pain was observed. Read The Article…
Serratiopeptidase: A Systematic Review of the Existing Evidence (2013)
Authors: S. Bhagat, S. Agarwal, S. Roy
Journal: International Journal of Surgery
Summary: This systematic review analyzed 24 studies on the clinical efficacy of serratiopeptidase. The findings suggested that while some studies reported positive outcomes regarding its anti-inflammatory and analgesic properties, many had methodological limitations, including small sample sizes and lack of standardized dosing. The review emphasized the need for more rigorous clinical trials to establish definitive conclusions. Read The Article…
Efficacy Evaluation of the Dose Regimen of Serratiopeptidase (Serodase 5 mg Tablet) in the Treatment of Inflammation After Third Molar Surgery (2015)
Sponsor: Hayat Pharmaceutical Co. PLC
Summary: This prospective, randomized, double-blind, placebo-controlled study aimed to examine the efficacy of a 5 mg dose regimen of serratiopeptidase in treating inflammation following third molar surgery. The study intended to assess outcomes such as trismus, swelling, and postoperative pain over a period of five days. Read The Article…
While these studies provide insights into the potential benefits of serratiopeptidase, it’s important to note that the existing body of research has limitations. Many studies have small sample sizes, varying methodologies, and inconsistent outcome measures. Therefore, further well-designed clinical trials are necessary to conclusively determine the efficacy and safety of serratiopeptidase for various medical conditions.
Taurine Clinical Research References
Taurine Clinical Research References
Taurine, a naturally occurring amino acid, has been the subject of various clinical studies exploring its potential health benefits. Here are some notable findings:
Type 2 Diabetes Management:
A study published in Nutrition & Metabolism investigated the effects of taurine supplementation in individuals with type 2 diabetes mellitus (T2DM). The results indicated significant reductions in insulin levels, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), oxidative stress, inflammation, and markers of endothelial dysfunction in the taurine-supplemented group compared to the placebo group. Read The Article…
Heart Failure and Cardiomyopathy:
A systematic review in Wellcome Open Research examined the impact of taurine administration on symptoms and clinical outcomes in patients with dilated cardiomyopathy and heart failure. The review suggested potential benefits of taurine supplementation in improving cardiac function and patient outcomes, though the authors called for more rigorous clinical trials to confirm these findings. Read The Article…
Perioperative Use:
A systematic review and meta-analysis assessed the effects of oral or intravenous taurine, or its derivative taurolidine, in the perioperative setting. The analysis aimed to determine whether these supplements could offer benefits compared to placebo during the perioperative period. While some positive effects were noted, the study emphasized the need for further research to draw definitive conclusions. Read The Article…
Neuroendocrine Effects:
An article in the Cleveland Clinic Journal of Medicine reviewed the neuroendocrine effects of taurine, particularly its abundance in the brain, retina, heart, and reproductive organs. The review highlighted taurine’s role as an inhibitory neurotransmitter and neuromodulator, noting its structural similarity to gamma-aminobutyric acid (GABA). The authors called for more research to fully understand taurine’s neuroendocrine impacts. Read The Article…
Anti-Aging Potential:
Research led by Columbia University, published in Science and summarized by ScienceDaily, found that taurine deficiency may drive aging in animals. Supplementation with taurine improved health and increased lifespan in worms, mice, and monkeys. While these findings are promising, the study’s lead author emphasized that only randomized clinical trials in humans will determine if taurine truly has health benefits related to aging. Read The Article…
These studies suggest that taurine supplementation may offer various health benefits, including improved metabolic control in diabetes, enhanced cardiac function, and potential anti-aging effects. However, further clinical trials are necessary to confirm these benefits and establish appropriate dosing guidelines.
How Covalent Can Help You Leverage These Trends
Covalent specializes in creating custom nutraceutical formulations with an emphasis on high-quality, cGMP-compliant manufacturing. Our state-of-the-art facility ensures the highest standards of safety, quality, and potency for every product. With low MOQ options, quick turnaround times, and the ability to incorporate cutting-edge ingredients like Nattokinase, Berberine, Quercetin, Serratiopeptidase, and Taurine, Covalent is here to help you create supplements that are not only effective but in line with the latest market trends.
As the demand for natural health products continues to grow, these ingredients offer tremendous potential. Let us help you tap into the thriving market of immune support, heart health, and metabolic wellness by creating a custom product that stands out from the competition.
Reach out to Covalent today to start developing your next high-demand supplement with these powerful ingredients. Together, we can bring your product to market quickly and efficiently!
About Rich Weisner
My goal is to help businesses scale and succeed by offering personalized support, industry knowledge, and access to cutting-edge manufacturing technology. Let’s connect and explore how we can collaborate to bring your product ideas to life!
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